Rigaud A S, Traykov L, Hanon O, Seux M L, Latour F, Lenoir H, Olde-Rikkert M, Forette F
Hôpital Broca, CHU Cochin Port-Royal, Université René Descartes, Paris V, 54/56, rue Pascal, 75013 Paris.
Arch Mal Coeur Vaiss. 2003 Jan;96(1):47-51.
The prevalence and incidence of degenerative and vascular dementia increase exponentially with age. Several studies in recent years have implicated hypertension as a risk factor not only for vascular dementia but also for degenerative dementia such as Alzheimer's disease. This is an important finding because it suggests that the treatment of hypertension could reduce the incidence of dementia. In particular, the results of the Syst-Eur study, showing that a calcium inhibitor, nitrendipine, could reduce not only the incidence of stroke but also that of dementia, should be confirmed.
退行性和血管性痴呆的患病率和发病率随年龄呈指数增长。近年来的几项研究表明,高血压不仅是血管性痴呆的危险因素,也是阿尔茨海默病等退行性痴呆的危险因素。这是一项重要发现,因为它表明治疗高血压可能会降低痴呆的发病率。特别是,Syst-Eur研究的结果显示,钙拮抗剂尼群地平不仅可以降低中风的发病率,还可以降低痴呆的发病率,这一结果应得到证实。