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[儿童克罗恩病]

[Crohn's disease in children].

作者信息

Rumiantsev V G, Shchigoleva N E

机构信息

Central Scientific Research Institute of Gastroenterology, Moscow.

出版信息

Eksp Klin Gastroenterol. 2002(5):97-102, 130.

Abstract

Crohn's disease is a chronic transmural inflammation that can involve any part of the digestive system, from the oral cavity to the anal canal, being combined with many abenteric manifestations. It can appear at any age. The first description of this disease in a teenager was made in 1834 by B.B. Crohn, and 11 years later a series of observations describing 48 children with this disease was published. The concept of the Crohn's disease as a non-children illness underwent a change with the widening of diagnostic possibilities, wide use of the endoscopic method of diagnostics in pediatric practice, and histological studies of biopsy materials. A steady growth of the frequency of Crohn's disease detections has been recorded since the middle of the 1980s. Morbidity in Great Britain and Sweden doubled reaching 3.1 for 100,000 infants, and in 1993 its spread made up 16.6 for 100,000.

摘要

克罗恩病是一种慢性透壁性炎症,可累及消化系统的任何部位,从口腔至肛管,并伴有多种肠外表现。它可在任何年龄出现。1834年,B.B.克罗恩首次描述了一名青少年患此病的情况,11年后,发表了一系列对48例患此病儿童的观察报告。随着诊断可能性的扩大、儿科实践中内镜诊断方法的广泛应用以及活检材料的组织学研究,克罗恩病作为一种非儿童疾病的概念发生了变化。自20世纪80年代中期以来,克罗恩病的检出率持续增长。英国和瑞典的发病率翻了一番,达到每10万名婴儿中有3.1例,1993年其发病率为每10万人中有16.6例。

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