Ni Nina, Yalkowsky Samuel H
College of Pharmacy, The University of Arizona, Tucson, AZ 85721, USA.
Int J Pharm. 2003 Mar 26;254(2):167-72. doi: 10.1016/s0378-5173(03)00008-5.
The Setschenow (salting out) constant by sodium chloride is related to molar volume, aqueous solubility, and octanol-water partition coefficient, K(ow), of the drug solute. This study validates a previously proposed relationship between the salting out constant of a solute and its partition coefficient. It also shows that the partition coefficient is a better descriptor of salting out than either molar volume or solubility.
氯化钠的盐析常数（Setschenow常数）与药物溶质的摩尔体积、水溶性及正辛醇-水分配系数K(ow)相关。本研究验证了先前提出的溶质盐析常数与其分配系数之间的关系。研究还表明，与摩尔体积或溶解度相比，分配系数是盐析更好的描述指标。
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