胰岛素抵抗与多囊卵巢综合征

Insulin resistance and polycystic ovary syndrome.

作者信息

Ehrmann David A

机构信息

Department of Medicine, Section of Endocrinology, University of Chicago Pritzker School of Medicine, 5841 South Maryland Avenue, MC 1027, Chicago, IL 60637, USA.

出版信息

Curr Diab Rep. 2002 Feb;2(1):71-6. doi: 10.1007/s11892-002-0061-y.

DOI:10.1007/s11892-002-0061-y

PMID:12643125

Abstract

Insulin resistance plays a central role in the pathogenesis of the reproductive as well as metabolic aberrations that characterize the syndrome. Many women with polycystic ovary syndrome (PCOS) manifest a phenotype that overlaps substantially with the so-called "metabolic syndrome" or "syndrome X." These manifestations include obesity, glucose intolerance, hypertension, macrovascular disease, and dyslipidemia. The etiology and manifestations of insulin resistance in PCOS are reviewed in this article.

摘要

胰岛素抵抗在该综合征所特有的生殖及代谢异常的发病机制中起核心作用。许多多囊卵巢综合征（PCOS）女性表现出的一种表型与所谓的“代谢综合征”或“X综合征”有很大重叠。这些表现包括肥胖、葡萄糖不耐受、高血压、大血管疾病和血脂异常。本文对PCOS中胰岛素抵抗的病因及表现进行了综述。