在一项基于社区的健康家庭研究中胰岛素抵抗综合征特征的遗传力。

Heritability of features of the insulin resistance syndrome in a community-based study of healthy families.

作者信息

Freeman M S, Mansfield M W, Barrett J H, Grant P J

机构信息

Academic Unit of Molecular Vascular Medicine, The General Infirmary at Leeds, University of Leeds, UK.

出版信息

Diabet Med. 2002 Dec;19(12):994-9. doi: 10.1046/j.1464-5491.2002.00843.x.

DOI:10.1046/j.1464-5491.2002.00843.x

PMID:12647839

Abstract

AIMS

To investigate genetic and environmental influences on anthropometric, metabolic and fibrinolytic traits of the insulin resistance syndrome (IRS) in a population not characterized by a high degree of insulin resistance.

METHODS

We recruited 537 adults from 89 randomly ascertained healthy families of white north European origin from the general population. We used maximum likelihood analysis to estimate the heritabilities and effects of environmental covariates on traits of the IRS in these families.

RESULTS

Adjusted for age, sex and body mass index, the traits showed considerable heritability. For waist-hip ratio, heritability was 15%. The heritabilities of fasting glucose, insulin and estimated insulin resistance were 20%, 23% and 23%, respectively. Heritabilities were 20%, 24% and 43% for triglycerides, LDL-cholesterol and HDL-cholesterol, respectively. For PAI-1 Ag and t-PA Ag they were 20% and 26%. Covariates explained 20-25% of the variance of lipids and insulin resistance and 35-36% of fibrinolytic factors. Childhood household influences significantly affected variance for waist-hip ratio (4%), fasting insulin (11%) and estimated insulin resistance (12%).

CONCLUSIONS

These family data demonstrate significant genetic influence on anthropometric, fibrinolytic and glucose-related traits of the IRS in a healthy white North European population.

摘要

目的

在一个未表现出高度胰岛素抵抗的人群中，研究遗传和环境因素对胰岛素抵抗综合征（IRS）的人体测量学、代谢和纤溶特性的影响。

方法

我们从一般人群中89个随机确定的、具有北欧白人血统的健康家庭招募了537名成年人。我们使用最大似然分析来估计这些家庭中环境协变量对IRS特性的遗传力和影响。

结果

校正年龄、性别和体重指数后，这些特性显示出相当高的遗传力。腰臀比的遗传力为15%。空腹血糖、胰岛素和估计的胰岛素抵抗的遗传力分别为20%、23%和23%。甘油三酯、低密度脂蛋白胆固醇和高密度脂蛋白胆固醇的遗传力分别为20%、24%和43%。纤溶酶原激活物抑制因子-1抗原（PAI-1 Ag）和组织型纤溶酶原激活物抗原（t-PA Ag）的遗传力分别为20%和26%。协变量解释了脂质和胰岛素抵抗变异的20%-25%以及纤溶因子变异的35%-36%。童年家庭影响显著影响腰臀比（4%）、空腹胰岛素（11%）和估计的胰岛素抵抗（12%）的变异。