马绍尔群岛居民及其他密克罗尼西亚人中“罕见”蛋白质变体的频率。

The frequency of "rare" protein variants in Marshall islanders and other Micronesians.

作者信息

Neel J V, Ferrell R E, Conard R A

出版信息

Am J Hum Genet. 1976 May;28(3):262-9.

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1685014/

Abstract

Blood specimens from a sample of 373 Marshall Islanders were studied with reference to variants of 23 serum proteins and erythrocyte enzymes. Six of the traits studied exhibited genetic polymorphisms (adenosine deaminase, phosphoglucomutase1, acid phosphatase, 6-phosphogluconate dehydrogenase, haptoglobin, and group specific component). There were in addition four "rare" variants (albumin, transferrin, lactate dehydrogenase, and galactose-1-phosphate uridylyltransferase) involving nine persons, among 8,503 determinations. The frequency of rare variants in Micronesians was compared with the frequencies in West European Caucasians and Amerindians. There are many difficulties in such comparisons, and although the observed values for the three ethnic groups differ by a factor of three (the Micronesians exhibiting the lowest frequency), it is felt that no firm conclusions concerning differences between ethnic groups can be drawn at this time.

摘要

对373名马绍尔群岛居民的血样进行了研究，检测了23种血清蛋白和红细胞酶的变体。所研究的性状中有6种表现出遗传多态性（腺苷脱氨酶、磷酸葡萄糖变位酶1、酸性磷酸酶、6-磷酸葡萄糖酸脱氢酶、触珠蛋白和组特异性成分）。此外，在8503次检测中，有4种“罕见”变体（白蛋白、转铁蛋白、乳酸脱氢酶和1-磷酸半乳糖尿苷酰转移酶）涉及9人。将密克罗尼西亚人中罕见变体的频率与西欧白种人和美洲印第安人的频率进行了比较。进行此类比较存在许多困难，尽管这三个种族群体的观察值相差三倍（密克罗尼西亚人频率最低），但目前认为无法就种族群体之间的差异得出确凿结论。