比较基因组学：后生动物真核生物的全基因组分析。
Comparative genomics: genome-wide analysis in metazoan eukaryotes.
作者信息
Ureta-Vidal Abel, Ettwiller Laurence, Birney Ewan
机构信息
EnsEMBL Project, Room A2-06, EMBL-European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
出版信息
Nat Rev Genet. 2003 Apr;4(4):251-62. doi: 10.1038/nrg1043.
The increasing number of complete and nearly complete metazoan genome sequences provides a significant amount of material for large-scale comparative genomic analysis. Finding new effective methods to analyse such enormous datasets has been the object of intense research. Three main areas in comparative genomics have recently shown important developments: whole-genome alignment, gene prediction and regulatory-region prediction. Each of these areas improves the methods of deciphering long genomic sequences and uncovering what lies hidden in them.
后生动物全基因组序列和近全基因组序列数量的不断增加，为大规模比较基因组分析提供了大量材料。寻找新的有效方法来分析如此庞大的数据集一直是深入研究的目标。比较基因组学的三个主要领域最近取得了重要进展：全基因组比对、基因预测和调控区域预测。这些领域中的每一个都改进了解读长基因组序列的方法，并揭示了其中隐藏的信息。
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