灰黄霉素对绵羊食用臂形草（俯仰臂形草）毒性的影响。

Effect of griseofulvin on the toxicity of signal grass (Brachiaria decumbens) in sheep.

作者信息

Haisah A H, Elsheikh H A, Khairi H M, Salam Abdullah A, Rajion M A

机构信息

Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, University Putra Malaysia, 43400 UPM Serdang, Selangor Darul Ehsan, Malaysia

出版信息

Vet Hum Toxicol. 2003 Mar;45(2):68-71.

PMID:12678289

Abstract

The effect of griseofulvin treatment on signal grass (Brachlaria decumbens) toxicity was studied in 27 male Wiltshire Indigenous Malaysian crossbred sheep. Grazing on signal grass generally decreased the activity of the drug metabolizing enzymes in livers and kidneys. Griseofulvin oral administration of 5 mg/kg body weight for 5 consecutive days every other week for 10 w increased the hepatic concentration of cytochrome P-450 and the activity of phase II drug metabolizing enzymes (UDP-glucuronyltransferase and glutathione-S-transferase) while it decreased the hepatic and increased the renal activity of phase I enzymes aminopyrine-N-demethylase and aniline-4-hydroxylase. Griseofulvin did not protect sheep against B decumbens toxicity as 5/7 animals treated with griseofulvin and grazed on B decumbens showed signs of the plant toxicity.

摘要

在27只雄性马来西亚威尔特郡本地杂交绵羊中研究了灰黄霉素治疗对臂形草（俯仰臂形草）毒性的影响。采食臂形草通常会降低肝脏和肾脏中药物代谢酶的活性。每隔一周连续5天口服5 mg/kg体重的灰黄霉素，持续10周，可增加细胞色素P-450的肝脏浓度和II相药物代谢酶（尿苷二磷酸葡萄糖醛酸基转移酶和谷胱甘肽-S-转移酶）的活性，同时降低I相酶氨基比林-N-脱甲基酶和苯胺-4-羟化酶的肝脏活性并增加其肾脏活性。灰黄霉素不能保护绵羊免受俯仰臂形草的毒性影响，因为7只接受灰黄霉素治疗并采食俯仰臂形草的动物中有5只出现了植物中毒迹象。