De Cock L, Vranckx R
Dept. of Microbiology, Section Virology, Scientific Institute of Public Health, Juliette Wytsmanstrasse 14, B-1050 Brussels, Belgium.
Infection. 2003 Mar;31(2):92-7. doi: 10.1007/s15010-002-3001-5.
Given that both pathogenicity and the response to treatment are possibly associated with hepatitis C virus (HCV) serotype, it appeared sensible to establish the prevalence of the different HCV types in Belgium.
The HCV serotypes were determined in 68 HCV-RNA and anti-HCV-positive samples taken from Belgian patients and compared with the results of the genotyping assay. Possible associations with age and sex were investigated.
Antibodies were identified in 55 (80.9%) of the 68 samples, with serotype 1 (58.8%) and serotype 3 (19.1%) showing the highest prevalence. 17 samples contained several serotypes with serotype 1 being detected in 82.4% of cases. Nine of the 11 samples undetermined by serotyping could be determined by genotyping. There was no significant difference in the distribution of HCV types with respect to gender. Compared with genotype 3 (p < 0.01) and genotypes 2 and 4 (p = 0.05), genotype 1 was detected among older patients.
Our data showed a 96.0% correlation between the serotyping and genotyping assays. Genotypes 1 and 3 are the most prevalent types among Belgian patients. The data suggest that genotype 1 spread earlier than genotypes 2, 3 and 4. This corroborates previous European studies.
鉴于丙型肝炎病毒（HCV）血清型可能与致病性及治疗反应均相关，因此确定比利时不同HCV类型的流行情况似乎是合理的。
对取自比利时患者的68份HCV-RNA和抗-HCV阳性样本进行HCV血清型测定，并与基因分型检测结果进行比较。研究了其与年龄和性别的可能关联。
68份样本中有55份（80.9%）检测出抗体，其中血清型1（58.8%）和血清型3（19.1%）的流行率最高。17份样本含有多种血清型，82.4%的病例检测出血清型1。11份血清分型未确定的样本中有9份可通过基因分型确定。HCV类型的分布在性别方面无显著差异。与基因型3（p < 0.01）以及基因型2和4（p = 0.05）相比，基因型1在老年患者中被检测到。
我们的数据显示血清分型和基因分型检测之间的相关性为96.0%。基因型1和3是比利时患者中最常见的类型。数据表明基因型1比基因型2、3和4传播得更早。这证实了先前的欧洲研究。
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