非整倍体基因组的内在不稳定性在癌症中是否具有因果作用？
Does the intrinsic instability of aneuploid genomes have a causal role in cancer?
作者信息
Matzke Marjori A, Mette M Florian, Kanno Tatsuo, Matzke Antonius J M
机构信息
Institute of Molecular Biology, Austrian Academy of Sciences, Billrothstrasse 11, A-5020 Salzburg, Austria.
出版信息
Trends Genet. 2003 May;19(5):253-6. doi: 10.1016/s0168-9525(03)00057-x.
Abstract
The role of aneuploidy in carcinogenesis has long been debated. We argue here that aneuploid genomes are naturally more susceptible to the types of chromosome rearrangement and epigenetic aberration that are found typically in tumor cells. In some cases, the formation of an aneuploid genome might be the initiating step in neoplastic conversion.
摘要
非整倍体在致癌过程中的作用长期以来一直存在争议。我们在此认为，非整倍体基因组天然更容易发生在肿瘤细胞中常见的染色体重排和表观遗传畸变类型。在某些情况下，非整倍体基因组的形成可能是肿瘤转化的起始步骤。
Zotero 插件