来自海洋真菌的新型抗真菌二酮哌嗪

Novel antifungal diketopiperazine from marine fungus.

作者信息

Byun Hee-Guk, Zhang Huiping, Mochizuki Masami, Adachi Kyoko, Shizuri Yoshikazu, Lee Won-Jae, Kim Se-Kwon

机构信息

Marine Biotechnology Institute Co. Ltd., Shimizu, Shizuoka 424-0037, Japan

出版信息

J Antibiot (Tokyo). 2003 Feb;56(2):102-6. doi: 10.7164/antibiotics.56.102.

DOI:10.7164/antibiotics.56.102

PMID:12715868

Abstract

Marine fungi producing antifungal compounds were screened against Pyricularia oryzae (P. oryzae), and a metabolite of marine fungus M-3 isolated from laver (Porphyra yezoensis) showed potent activity. Novel diketopiperazine (1) was isolated from the culture extracts, and its structure was elucidated by spectroscopic methods. The MIC of 1 against P. oryzae was 0.36 microM.

摘要

针对稻瘟病菌对产生抗真菌化合物的海洋真菌进行了筛选，从紫菜（条斑紫菜）中分离出的海洋真菌M-3的一种代谢产物显示出强效活性。从培养提取物中分离出新型二酮哌嗪（1），并通过光谱方法阐明了其结构。1对稻瘟病菌的最小抑菌浓度为0.36微摩尔。