西诺沙星、萘啶酸和恶喹酸的体外比较研究。
Comparative in vitro studies of cinoxacin, nalidixic acid, and oxolinic acid.
作者信息
Gordon R C, Stevens L I, Edmiston C E, Mohan K
出版信息
Antimicrob Agents Chemother. 1976 Dec;10(6):918-20. doi: 10.1128/AAC.10.6.918.
Cinoxacin and nalidixic acid were found to be similar in in vitro activity against 138 Shigella isolates and somewhat less active than oxolinic acid on a weight basis. Cross-resistance developed when 10 shigellae were transferred on increasing amounts of the respective agent contained in Mueller-Hinton agar. Plate dilution studies of the effect of changes in agar pH on the minimum inhibitory concentration revealed that the antibacterial activity increased with decreasing pH. Protein binding investigations revealed a high degree of binding, with nalidixic acid > oxolinic acid > cinoxacin.
研究发现，环丙沙星和萘啶酸对138株志贺氏菌分离株的体外活性相似，按重量计算，其活性略低于恶喹酸。当10株志贺氏菌在含有相应药物且剂量不断增加的穆勒-欣顿琼脂上传代时，会产生交叉耐药性。平板稀释法研究琼脂pH值变化对最低抑菌浓度的影响表明，抗菌活性随pH值降低而增强。蛋白质结合研究显示，结合程度很高，萘啶酸>恶喹酸>环丙沙星。
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