白果紫萁醇是一种来自买麻藤属的强效酪氨酸酶抑制剂。

Gnetol as a potent tyrosinase inhibitor from genus Gnetum.

作者信息

Ohguchi Kenji, Tanaka Toshiyuki, Iliya Ibrahim, Ito Tetsuro, Iinuma Munekazu, Matsumoto Kenji, Akao Yukihiro, Nozawa Yoshinori

机构信息

Gifu International Institute of Biotechnology, Mitake, Kani-gun, Gifu 505-0116, Japan.

出版信息

Biosci Biotechnol Biochem. 2003 Mar;67(3):663-5. doi: 10.1271/bbb.67.663.

DOI:10.1271/bbb.67.663

PMID:12723623

Abstract

Gnetol (2,3',5',6-tetrahydroxy-trans-stilbene), a naturally occurring compound particularly found in the genus Gnetum, had a strong inhibitory effect on murine tyrosinase activity. Gnetol (IC50, 4.5 microM) was stronger than kojic acid (IC50, 139 microM) as a standard inhibitor for murine tyrosinase activity. Moreover, gnetol significantly suppressed, melanin biosynthesis in murine B16 melanoma cells.

摘要

去甲二氢愈创木酸（2,3',5',6 - 四羟基反式芪）是一种天然存在的化合物，尤其在买麻藤属植物中发现，它对小鼠酪氨酸酶活性具有强烈的抑制作用。作为小鼠酪氨酸酶活性的标准抑制剂，去甲二氢愈创木酸（IC50为4.5微摩尔）比曲酸（IC50为139微摩尔）的抑制作用更强。此外，去甲二氢愈创木酸显著抑制小鼠B16黑色素瘤细胞中的黑色素生物合成。