滇西乌头碱，一种从滇西乌头中提取的具有8-氨基的新型C19-二萜生物碱。

Hemsleyatine, a novel C19-diterpenoid alkaloid with 8-amino group from Aconitum hemsleyanum.

作者信息

Zhou Xian-Li, Chen Qiao-Hong, Chen Dong-Lin, Wang Feng-Peng

机构信息

Department of Bioengineering, Southwest Jiaotong University, Chengdu, P.R. China.

出版信息

Chem Pharm Bull (Tokyo). 2003 May;51(5):592-4. doi: 10.1248/cpb.51.592.

DOI:10.1248/cpb.51.592

PMID:12736463

Abstract

The new compound hemsleyatine (1) was isolated along with four known C(19)-diterpenoid alkaloids: indaconitine (4), yunaconitine (5), chasmanine (6), and talatisamine (7) from the roots of Aconitum hemsleyanum PRITZ. Structures were established by spectral analysis, including tow dimeusional (2D) NMR spectroscopy and a chemical method. Hemsleyatine (1) is the first C(19)-diterpenoid alkaloid bearing the 8-amino group. In addition, the assignments of some (13)C signals for pseudaconine (3) were revised by comparison with those of hemsleyatine (1).

摘要

从滇西乌头（Aconitum hemsleyanum PRITZ.）的根中分离得到了新化合物滇西乌头碱（1）以及四种已知的C(19)-二萜生物碱：印乌碱（4）、云乌碱（5）、查斯曼宁（6）和塔拉胺（7）。通过光谱分析，包括二维（2D）核磁共振光谱和化学方法确定了结构。滇西乌头碱（1）是首个带有8-氨基的C(19)-二萜生物碱。此外，通过与滇西乌头碱（1）的信号进行比较，对伪乌头碱（3）的一些(13)C信号归属进行了修订。