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[乌克兰顿涅茨克地区两个城市人群中AB0和RH血型等位基因的基因频率与杂合性]

[Gene frequencies and heterozygosity of the AB0 and RH blood group alleles in the populations of two cities of the Donetsk region, Ukraine].

作者信息

Mukhin V N, Chinakh D G, Avdeev A V, Kuleba V V, Afanas'ev M V

机构信息

Gorky State Medical University, Donetsk, 83003 Ukraine.

出版信息

Genetika. 2003 Apr;39(4):530-3.

Abstract

The frequencies of the AB0 and RH blood group alleles and heterozygosity indices were determined for the populations of two large industrial cities of Gorlovka and Mariupol. In the population of Gorlovka the gene frequencies were as follows: AB00 = 0.576, AB0A = 0.266, AB0B = 0.158, and RHD = 0.592, in Mariupol the frequencies were AB00 = 0.584, AB0A = 0.265, AB0B = 0.151, and RHD = 0.604. In Gorlovka the heterozygosity indices in respect to the AB0 and RH alleles were 0.572 and 0.483, respectively; in Mariupol, 0.566 and 0.478, respectively. There were no statistically significant differences between the two populations in respect to the genetic markers analyzed. However, the heterozygosity values obtained were more similar to the corresponding estimates for some populations of Russia, than for the total population of the Ukraine.

摘要

测定了戈尔洛夫卡和马里乌波尔这两个大型工业城市人群的AB0和RH血型等位基因频率以及杂合度指数。在戈尔洛夫卡人群中,基因频率如下:AB00 = 0.576,AB0A = 0.266,AB0B = 0.158,RHD = 0.592;在马里乌波尔,频率分别为AB00 = 0.584,AB0A = 0.265,AB0B = 0.151,RHD = 0.604。在戈尔洛夫卡,AB0和RH等位基因的杂合度指数分别为0.572和0.483;在马里乌波尔,分别为0.566和0.478。在所分析的遗传标记方面,这两个人群之间没有统计学上的显著差异。然而,所获得的杂合度值与俄罗斯一些人群的相应估计值相比,比与乌克兰总人口的相应估计值更相似。

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