锌对铅抑制人δ-氨基乙酰丙酸脱水酶的体外作用。
The in vitro effect of zinc on the inhibition of human delta-aminolevulinic acid dehydratase by lead.
作者信息
Border E A, Cantrell A C, Kilroe-Smith T A
出版信息
Br J Ind Med. 1976 May;33(2):85-7. doi: 10.1136/oem.33.2.85.
The antagonistic effect of zinc on inhibibition of human aminolevulinic acid dehydratase (ALAD) by lead was examined in vitro. The phenomenon was studied at pH 6.5-7.5 . Zinc and lead were added at concentrations ranging from physiological levels to levels far in excess of those expected in heavy industrial exposure. ALAD activity of normal blood assayed in the presence of zinc was unaffected by exogenous lead if the added zinc concentration was above 0.53 mmol/l blood, or double the normal endogenous level, and was of the order found in heavy industrial exposure to zinc. In this case, ALAD assay values were appreciably raised and might have fallen into the normal range in spite of a dangerous total blood lead of over 0.0048 mmol/l. When zinc was added in vitro to blood from a worker with a blood lead level of 0.0043 mmol/l the ALAD values obtained were also raised and did not reflect the dangerous level of lead in the patient.
在体外研究了锌对铅抑制人δ-氨基-γ-酮戊酸脱水酶（ALAD）的拮抗作用。该现象在pH 6.5 - 7.5条件下进行研究。锌和铅的添加浓度范围从生理水平到远远超过重工业暴露预期的水平。如果添加的锌浓度高于0.53 mmol/L血液（即正常内源性水平的两倍），且处于重工业锌暴露时发现的浓度水平，那么在锌存在的情况下测定的正常血液的ALAD活性不受外源性铅的影响。在这种情况下，尽管全血铅含量危险地超过了0.0048 mmol/L，但ALAD测定值明显升高，可能已落入正常范围。当在体外向一名血铅水平为0.0043 mmol/L的工人的血液中添加锌时，获得的ALAD值也升高了，没有反映出患者体内铅的危险水平。
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