应答还是不应答：过敏性哮喘中的T细胞

To respond or not to respond: T cells in allergic asthma.

作者信息

Herrick Christina A, Bottomly Kim

机构信息

Department of Dermatology, Yale University School of Medicine, 300 Cedar Street, New Haven, Connecticut 06520, USA.

出版信息

Nat Rev Immunol. 2003 May;3(5):405-12. doi: 10.1038/nri1084.

DOI:10.1038/nri1084

PMID:12766762

Abstract

The incidence of allergic asthma has almost doubled in the past two decades. Numerous epidemiological studies have linked the recent surge in atopic disease with decreased exposure to infections in early childhood as a result of a more westernized lifestyle. However, a clear mechanistic explanation for how this might occur is still lacking. An answer might lie in the presently unfolding story of various regulatory T-cell populations that can limit adaptive immune responses, including T helper 2 (T(H)2)-cell-mediated allergic airway disease.

摘要

在过去二十年中，过敏性哮喘的发病率几乎翻了一番。大量流行病学研究将近期特应性疾病的激增与儿童早期因生活方式更加西化而接触感染减少联系起来。然而，对于这种情况可能如何发生，仍缺乏明确的机制解释。答案可能在于目前正在展开的各种调节性T细胞群体的情况，这些群体可以限制适应性免疫反应，包括辅助性T细胞2（Th2）介导的过敏性气道疾病。