米非司酮对人早孕胎盘霍夫鲍尔细胞超微结构的影响
[Effects of mifepristone on ultrastructure of placental Hofbauer cells in early human pregnancy].
作者信息
Jia Jian-Jun, Wang Zi-Neng
机构信息
Department of Obstetrics and Gynecology, First Affiliated Hospital, Medical College Jinan University, Guangzhou 510632, China.
出版信息
Zhonghua Fu Chan Ke Za Zhi. 2003 Feb;38(2):92-3, 2-1.
OBJECTIVE
To investigate the effects of mifepristone on the ultrastructure of Hofbauer cells in human early pregnant placenta.
METHODS
Twenty 6 - 9 week pregnant women with indications of pregnancy termination were recruited and randomly assigned to mifepristone group(n = 10) and D & C group (n = 10). Villi were collected and studied with transmission electron microscope.
RESULTS
In comparison with the control group, the ultrastructure of Hofbauer cells of mifepristone group showed the following changes: the cells were markedly edematous. The number of cytoplasmic processes of Hofbauer cells deceased obviously. In the cytoplasm of Hofbauer cells, the size of vacuoles enlarged and of mitochondria minimized. Rough endoplasmic reticulum and Golgi complex were under-developed. Lysosomes were rare. The nuclei enlarged and showed irregular shape.
CONCLUSIONS
Mifepristone may change the phagocytosis' water and electrolyte transportation and immunological function of Hofbauer cells by influencing the ultrastructure of the Hofbauer cells. Therefore it can influence the development of pregnancy.
目的
探讨米非司酮对人早孕胎盘绒毛膜细胞超微结构的影响。
方法
选取20例有终止妊娠指征的6 - 9周孕妇，随机分为米非司酮组（n = 10）和刮宫组（n = 10）。收集绒毛，用透射电子显微镜进行观察研究。
结果
与对照组相比，米非司酮组绒毛膜细胞超微结构有如下改变：细胞明显水肿；绒毛膜细胞的胞质突起数量明显减少；绒毛膜细胞胞质内，空泡变大，线粒体变小；粗面内质网和高尔基体发育不良；溶酶体少见；细胞核增大，形状不规则。
结论
米非司酮可能通过影响绒毛膜细胞超微结构，改变其吞噬、水和电解质转运及免疫功能，从而影响妊娠的发展。
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