Cornelius Marie D, Goldschmidt Lidush, Dempsey Delia A
Department of Psychiatry, University of Pittsburgh School of Medicine, PA, USA.
Nicotine Tob Res. 2003 Jun;5(3):333-9. doi: 10.1080/1462220031000094141.
We examined the prevalence and level of environmental tobacco smoke (ETS) exposure using urine cotinine levels in children and three types of maternal self-reports in a sample of 196 low socioeconomic status (SES) mothers and their children. The self-reports were report of the mother's own smoking, report of the number of household smokers, and report of the usual number of daily hours that the child was exposed to ETS. According to the reports, 59% of the children's mothers were current smokers, 71% of the children came from households with smokers, and 85% had daily exposure to ETS. Based on urine cotinine measures adjusted for creatinine, 79% of the children were identified as ETS exposed. The average urine cotinine level was 19.6 ng/mg, and the median cotinine level was 13.1 ng/mg (range: 0-120 ng/mg). Correlations between urine cotinine levels and the three maternal reports were 0.48, 0.43, and 0.36, respectively. The most sensitive maternal report measure was number of hours of exposure per day when using adjusted urine cotinine levels of >/=5 ng/mg were used as the yardstick of exposure. Of the 154 children screened at the level of >/=5 ng/mg, 89.5% were also identified by maternal report as ETS exposed. However, 30 children whose mothers reported ETS exposure had urine cotinine levels of <5 ng/mg. These data showed that ETS exposure was prevalent in low-SES children and that the maternal reports identified a higher number of children as ETS exposed. The biological measures provided data on levels of recent exposure; however, level of exposure from biological measures correlated only moderately with the maternal report. A combination of a maternal report and a biological measure is suggested as the most informative estimate of ETS exposure in young children.
我们在196名社会经济地位较低(SES)的母亲及其子女样本中,通过检测儿童尿液中可替宁水平以及三种类型的母亲自我报告,来研究环境烟草烟雾(ETS)暴露的患病率和水平。自我报告包括母亲自己的吸烟情况报告、家庭吸烟者数量报告以及孩子通常每天暴露于ETS的小时数报告。根据这些报告,59%的儿童母亲为当前吸烟者,71%的儿童来自有吸烟者的家庭,85%的儿童每天暴露于ETS。根据针对肌酐调整后的尿液可替宁测量结果,79%的儿童被确定为暴露于ETS。尿液可替宁平均水平为19.6 ng/mg,可替宁中位数水平为13.1 ng/mg(范围:0 - 120 ng/mg)。尿液可替宁水平与三种母亲报告之间的相关性分别为0.48、0.43和0.36。当使用调整后的尿液可替宁水平≥5 ng/mg作为暴露标准时,最敏感的母亲报告指标是每天的暴露小时数。在154名筛查水平≥5 ng/mg的儿童中,89.5%也被母亲报告确定为暴露于ETS。然而,有30名母亲报告其暴露于ETS的儿童尿液可替宁水平<5 ng/mg。这些数据表明,低SES儿童中ETS暴露很普遍,并且母亲报告确定为暴露于ETS的儿童数量更多。生物学测量提供了近期暴露水平的数据;然而,生物学测量的暴露水平与母亲报告仅呈中等程度相关。建议将母亲报告和生物学测量结合起来,作为对幼儿ETS暴露最具信息量的估计。