用于兔结膜伤口闭合的2-辛基氰基丙烯酸酯粘合剂
2-octyl cyanoacrylate adhesive for conjunctival wound closure in rabbits.
作者信息
Kim Yuri M, Gupta Balaji K
机构信息
Department of Ophthalmology & Visual Sciences, University of Illinois at Chicago, USA.
出版信息
J Pediatr Ophthalmol Strabismus. 2003 May-Jun;40(3):152-5. doi: 10.3928/0191-3913-20030501-09.
PURPOSE
To evaluate the efficacy and histology of 2-octyl cyanoacrylate in conjunctival wound closure in rabbits.
METHODS
Ten eyes of 10 New Zealand white rabbits were used. Eight rabbits had conjunctival wounds that were repaired with 2-octyl cyanoacrylate. Two rabbits were killed at 1 week and two rabbits were killed at 2 weeks and their conjunctivae were examined histologically. From two additional rabbits, conjunctival strips were obtained that underwent tensile strength testing.
RESULTS
All conjunctival wounds closed well with 2-octyl cyanoacrylate. Histology revealed minimal inflammation of the wounds. The tensile strength of conjunctival strips glued together was 25.5 g (standard deviation, 1.9 g).
CONCLUSION
2-Octyl cyanoacrylate may be a possible tissue adhesive for conjunctival wound closure.
目的
评估2-氰基丙烯酸辛酯用于兔结膜伤口闭合的疗效及组织学情况。
方法
使用10只新西兰白兔的10只眼睛。8只兔子的结膜伤口用2-氰基丙烯酸辛酯修复。2只兔子在1周时处死，2只兔子在2周时处死，对其结膜进行组织学检查。从另外2只兔子获取结膜条进行拉伸强度测试。
结果
所有结膜伤口用2-氰基丙烯酸辛酯均愈合良好。组织学显示伤口炎症轻微。粘贴在一起的结膜条的拉伸强度为25.5克（标准差1.9克）。
结论
2-氰基丙烯酸辛酯可能是一种用于结膜伤口闭合的组织粘合剂。
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