Swamy Priya A, Nardino Robert
Thomas Jefferson University Hospital, Philadelphia, Penn., USA.
Conn Med. 2003 May;67(5):263-4.
A 42-year-old man with chronic myelogenous leukemia presented to the hospital with hip pain. After undergoing surgical repair for a hip fracture, he developed aphasia, facial droop and fever. He was initially diagnosed with a stroke. A lumbar puncture excluded common infections, and an ELISA test for HIV was negative. Serial MRI scans revealed a progressive demyelinating pattern. Polymerase chain reaction performed on cerebrospinal fluid was positive for the JC virus (JC are the initials of the first person diagnosed with this virus). The patient was treated with cidofovir but died before a full course could be administered. JC virus is present in most adult hosts but is only harmful in immuno-compromised hosts. The active form of the disease is known as progressive multifocal leukoencephalopathy. This is the first reported case of a patient developing progressive multifocal leukoencephalopathy. with chronic myelogenous leukemia as the only underlying condition.
一名42岁的慢性粒细胞白血病男性因髋部疼痛入院。在接受髋部骨折手术修复后，他出现了失语、面部下垂和发热症状。他最初被诊断为中风。腰椎穿刺排除了常见感染，HIV酶联免疫吸附试验结果为阴性。系列磁共振成像扫描显示出进行性脱髓鞘模式。脑脊液聚合酶链反应检测显示JC病毒呈阳性（JC是首个被诊断感染此病毒患者名字的首字母）。患者接受了西多福韦治疗，但在完成整个疗程前死亡。JC病毒存在于大多数成年宿主中，但仅在免疫功能低下的宿主中具有危害性。该疾病的活跃形式被称为进行性多灶性白质脑病。这是首例报告的仅以慢性粒细胞白血病为基础疾病而发生进行性多灶性白质脑病的病例。
