Conejo M Carmen, García Isabel, Martínez-Martínez Luis, Picabea Leandro, Pascual Alvaro
Department of Microbiology, School of Medicine, University of Seville, Seville, Spain.
Antimicrob Agents Chemother. 2003 Jul;47(7):2313-5. doi: 10.1128/AAC.47.7.2313-2315.2003.
The activities of carbapenems against Pseudomonas aeruginosa decreased in the presence of siliconized latex urinary catheters (SLUCs). This effect was associated with the loss of OprD. The zinc that eluted from SLUCs is responsible for this phenomenon. We have found that zinc exerts a negative effect on the expression of OprD, the porin responsible for carbapenem entry into P. aeruginosa.
在硅化乳胶导尿管(SLUCs)存在的情况下,碳青霉烯类药物对铜绿假单胞菌的活性降低。这种效应与外膜孔蛋白D(OprD)的缺失有关。从SLUCs中洗脱出来的锌是造成这种现象的原因。我们发现,锌对OprD的表达产生负面影响,而OprD是碳青霉烯类药物进入铜绿假单胞菌的孔蛋白。