Gray Jeffrey L, Almstead Ji In K, Gallagher Corey P, Hu X Eric, Kim Nick K, Taylor Cynthia J, Twinem Tracy L, Wallace Cynthia D, Ledoussal Benoit
Procter & Gamble Pharmaceuticals, 8700Mason-Montgomery Rd, 45040, Mason, OH, USA.
Bioorg Med Chem Lett. 2003 Jul 21;13(14):2373-5. doi: 10.1016/s0960-894x(03)00399-8.
Quinolones without the usual 6-fluorine substituent have been recently described as potent antibacterial agents. A series of non-fluorinated analogues of the antibacterial quinolone Levofloxacin were synthesized and tested.
最近有报道称，没有常见6-氟取代基的喹诺酮类药物是强效抗菌剂。合成并测试了一系列抗菌喹诺酮左氧氟沙星的非氟化类似物。
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