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Cotrel-Dubousset器械治疗特发性脊柱侧凸的生存分析。

Survivorship analysis of Cotrel-Dubousset instrumentation in idiopathic scoliosis.

作者信息

Bago J, Ramirez M, Pellise F, Villanueva C

机构信息

Hospital de Traumatologia Vall d'Hebron, Barcelona, Spain.

出版信息

Eur Spine J. 2003 Aug;12(4):435-9. doi: 10.1007/s00586-001-0374-6. Epub 2003 Jun 21.

Abstract

This study presents a survivorship analysis of Cotrel-Dubousset instrumentation in the surgical treatment of idiopathic scoliosis. Between 1987 and 1995, a total of 133 patients with idiopathic scoliosis received posterior spine fusion and instrumentation with the CD system at our center. The patients' mean age at surgery was 16.5 years (range 11-43 years). The magnitude of the thoracic scoliosis averaged 62.7 degrees (range 40 degrees -125 degrees ) and that of the lumbar curve was 58.8 degrees (range 40 degrees -100 degrees ). On average, 12.2 segments were fused (range 8-17) and, excluding the rods, 14.1 implants were set for each patient (range 10-21). Survivorship analysis was carried out using the Kaplan-Meier method. Implant removal was considered the terminal event, or "death". The effect of several variables on survival rate was determined with the Cox regression method. The patients remained in the study for 56.7 months (range 2-120 months). One-hundred and ten patients were withdrawn ("censored"): 90 "alive" (did not require repeat surgery and attended follow-up control in 1997) and 20 "lost" (did not attend control in 1997). Twenty-three patients attained the terminal event of implant removal for a variety of reasons: acute infection (three cases), late infection (ten cases), implant failure requiring revision (six cases) and local pain (four cases). The survival rate was 95.5% at 3 months, 94.7% at 6 months, 93.9% at 1 year, 91.5% at 2 years, 82.2% at 5 years and 76.5% at 10 years. The magnitude of the curves, total number of implants and number of fused segments did not correlate with survival probability. A positive correlation was found between survival rate and correction loss between surgery and last control. A survival rate of 76.5% at 10 years is unexpectedly low. Current data suggest that the incapacity to maintain correction after initial surgery plays a major roll in the long-term evolution of Cotrel-Dubousset instrumentation.

摘要

本研究对Cotrel-Dubousset器械在特发性脊柱侧凸手术治疗中的生存率进行了分析。1987年至1995年间,共有133例特发性脊柱侧凸患者在本中心接受了后路脊柱融合术及CD系统器械植入。患者手术时的平均年龄为16.5岁(范围11 - 43岁)。胸段脊柱侧凸的角度平均为62.7度(范围40度 - 125度),腰段弯曲度为58.8度(范围40度 - 100度)。平均融合12.2个节段(范围8 - 17个),每位患者除棒外平均植入14.1个植入物(范围10 - 21个)。采用Kaplan-Meier方法进行生存率分析。植入物取出被视为终点事件,即“死亡”。用Cox回归方法确定几个变量对生存率的影响。患者参与研究的时间为56.7个月(范围2 - 120个月)。110例患者退出(“截尾”):90例“存活”(不需要再次手术且参加了1997年的随访控制),20例“失访”(未参加1997年的控制)。23例患者因各种原因达到了植入物取出的终点事件:急性感染(3例)、晚期感染(10例)、植入物失败需要翻修(6例)和局部疼痛(4例)。3个月时生存率为95.5%,6个月时为94.7%,1年时为93.9%,2年时为91.5%,5年时为82.2%,10年时为76.5%。弯曲度、植入物总数和融合节段数与生存概率无关。发现生存率与手术至最后一次控制时的矫正丢失之间存在正相关。10年时76.5%的生存率出乎意料地低。目前的数据表明,初次手术后无法维持矫正在Cotrel-Dubousset器械的长期演变中起主要作用。

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