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胆管结石的自然排出:发生率及其与临床表现的关系

Spontaneous passage of bile duct stones: frequency of occurrence and relation to clinical presentation.

作者信息

Tranter S E, Thompson M H

机构信息

Department of Surgery, North Bristol Trust, Southmead Hospital, Bristol, UK.

出版信息

Ann R Coll Surg Engl. 2003 May;85(3):174-7. doi: 10.1308/003588403321661325.

Abstract

BACKGROUND

Little is known about the spontaneous passage of bile duct stones. The aim of this study was to determine the rate of spontaneous stone passage and relate it to the clinical presentation of the bile duct stone.

PATIENTS AND METHODS

Prospectively collected data were studied on a total of 1000 consecutive patients undergoing laparoscopic cholecystectomy with or without laparoscopic common duct exploration. Comparisons were made between 142 patients with common bile duct stones (CBDS), 468 patients who had no previous or current evidence of duct stones, and 390 patients who had good evidence of previous duct stones but none at the time of cholecystectomy. The evidence used for previous duct stones included a good history of jaundice or pancreatitis. In patients with biliary colic or cholecystitis, abnormal pre-operative liver function tests and/or a dilated common bile duct were taken as evidence of bile duct stones.

RESULTS

Of the 1000 patients studied, 532 had evidence of stones in the common bile duct at some time prior to cholecystectomy. At the time of operation, only 142 patients had bile duct stones. By implication, 80%, 84%, 93% and 55% of patients presenting with pancreatitis, colic, cholecystitis and jaundice (73% overall) had passed their bile duct stones spontaneously. All 4 patients with cholangitis had duct stones at the time of operation.

CONCLUSIONS

It is likely that most bile duct stones (3 in 4) pass spontaneously, especially after pancreatitis, biliary colic and cholecystitis but less commonly after jaundice. Cholangitis appears to be always associated with the presence of duct stones at the time of operation.

摘要

背景

关于胆管结石的自然排出情况,人们了解甚少。本研究的目的是确定结石自然排出率,并将其与胆管结石的临床表现相关联。

患者与方法

前瞻性收集了总共1000例连续接受腹腔镜胆囊切除术(无论是否进行腹腔镜胆总管探查)患者的数据。对142例胆总管结石(CBDS)患者、468例既往或当前无胆管结石证据的患者以及390例既往有胆管结石充分证据但在胆囊切除术时无结石的患者进行了比较。用于证明既往胆管结石的证据包括黄疸或胰腺炎的良好病史。在患有胆绞痛或胆囊炎的患者中,术前肝功能检查异常和/或胆总管扩张被视为胆管结石的证据。

结果

在研究的1000例患者中,532例在胆囊切除术之前的某个时间有胆总管结石证据。手术时,只有142例患者有胆管结石。这意味着,出现胰腺炎、绞痛、胆囊炎和黄疸的患者中,分别有80%、84%、93%和55%(总体为73%)的胆管结石已自然排出。所有4例胆管炎患者在手术时均有胆管结石。

结论

很可能大多数胆管结石(四分之三)会自然排出,尤其是在胰腺炎、胆绞痛和胆囊炎之后,但在黄疸之后较少见。胆管炎似乎在手术时总是与胆管结石的存在相关。

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