吡咯-咪唑聚酰胺对DNA小沟的识别
Recognition of the DNA minor groove by pyrrole-imidazole polyamides.
作者信息
Dervan Peter B, Edelson Benjamin S
机构信息
Division of Chemistry and Chemical Engineering, and Beckman Institute, California Institute of Technology, Pasadena, CA 91125, USA.
出版信息
Curr Opin Struct Biol. 2003 Jun;13(3):284-99. doi: 10.1016/s0959-440x(03)00081-2.
Abstract
Many diseases, such as cancer, are related to aberrant gene expression. Regulating transcription by chemical methods could be important in human medicine. Minor groove-binding polyamides offer one chemical approach to DNA recognition.
摘要
许多疾病，如癌症，都与异常的基因表达有关。通过化学方法调控转录在人类医学中可能具有重要意义。小沟结合聚酰胺提供了一种识别DNA的化学方法。
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