烹饪与葡萄膜黑色素瘤风险：两项德国病例对照研究的结果

Cooking and uveal melanoma risk: results from two German case-control studies.

作者信息

Stang Andreas, Ahrens Wolfgang, Baumgardt-Elms Cornelia, Stegmaier Christa, Bornfeld Norbert, Schmidt-Pokrzywniak Andrea, Jöckel Karl-Heinz

机构信息

Institute for Medical Informatics, Biometry and Epidemiology, Medical Faculty, University of Essen, Germany.

出版信息

Cancer Causes Control. 2003 May;14(4):377-80. doi: 10.1023/a:1023912232258.

DOI:10.1023/a:1023912232258

PMID:12846370

Abstract

OBJECTIVE

Two recent studies indicated that cooks may have an increased risk of uveal melanoma. Here we report findings of two German case-control studies regarding cooking and uveal melanoma risk.

METHODS

We conducted a hospital and population-based case-control study of uveal melanoma and occupational exposures. We then pooled these results. Overall, 118 cases and 475 controls matching on age, sex and study regions were interviewed. We classified subjects as exposed to an occupational category (i.e. cooks) if they had ever worked within this category for at least six months or more. Subjects who had worked as cooks were rated as either (a) having prepared food without having cooked and therefore unexposed to cooking or (b) having cooked. We used conditional logistic regression models to calculate pooled odds ratios (OR) and 95% confidence intervals (95% CI).

RESULTS

Subjects who had ever cooked had an OR of 6.1 (95% CI: 1.7-22.2). Cooking was associated with an OR of 4.0 (95% CI: 0.8-20.1) for a job duration of 0.5-2 years and with an OR of 11.4 (95% CI: 1.6-81.9) for a job duration more than 2 years.

CONCLUSIONS

In light of the similar finding in other studies, the association deserves further attention.

摘要

目的

最近的两项研究表明，厨师患葡萄膜黑色素瘤的风险可能增加。在此，我们报告两项关于烹饪与葡萄膜黑色素瘤风险的德国病例对照研究的结果。

方法

我们开展了一项基于医院和人群的葡萄膜黑色素瘤与职业暴露的病例对照研究。然后汇总这些结果。总体而言，对118例病例和475例在年龄、性别和研究地区相匹配的对照进行了访谈。如果受试者曾在某职业类别（即厨师）工作至少六个月或更长时间，则将其归类为暴露于该职业类别。曾担任厨师的受试者被评定为要么（a）准备食物但未烹饪，因此未接触烹饪，要么（b）烹饪过。我们使用条件逻辑回归模型计算汇总比值比（OR）和95%置信区间（95%CI）。