Radmacher Paula G, Looney Stephen W, Rafail Salisa T, Adamkin David H
Department of Pediatrics, University of Louisville School of Medicine, Louisville, KY 40292, USA.
J Perinatol. 2003 Jul-Aug;23(5):392-5. doi: 10.1038/sj.jp.7210947.
Long-term growth failure in very very low birth weight (VVLBW) infants is a common complication of extreme prematurity. Critical illnesses create challenges to adequate nutriture.
To identify predictors of extrauterine growth retardation (EUGR) in VVLBW infants and to evaluate their nutritional intake and subsequent growth.
A 4-year retrospective chart review of 221 infants <or=1000 g birth weight and <or=29 weeks gestational age who were admitted within 24 hours of birth, were free of major congenital anomalies and survived at least 7 days. Daily intakes and anthropomorphic data were collected and analyzed. Significant events during hospitalization were documented.
Mean energy and protein intakes during hospitalization did not reach recommendations of 120 kcal/kg/d and 3.0 g/kg/day. In utero growth rates could not be consistently reached or sustained. As expected, BW (as measured by BW percentile score) was highly predictive of EUGR (p<0.001). When the independent effect of other predictors of EUGR was considered, only days of total parenteral nutrition (p<0.001) and HC percentile at return to birth weight (p<0.001) made a significant contribution to the prediction of EUGR, once the effect of BW was taken into account.
极低出生体重（VVLBW）婴儿的长期生长发育迟缓是极早产儿常见的并发症。危重症对充足营养构成挑战。
确定VVLBW婴儿宫外生长迟缓（EUGR）的预测因素，并评估其营养摄入及随后的生长情况。
对221例出生体重≤1000g且胎龄≤29周、出生后24小时内入院、无重大先天性异常且存活至少7天的婴儿进行为期4年的回顾性病历审查。收集并分析每日摄入量和人体测量数据。记录住院期间的重大事件。
住院期间的平均能量和蛋白质摄入量未达到120kcal/kg/d和3.0g/kg/天的推荐量。宫内生长速率未能持续达到或维持。正如预期的那样，出生体重（以出生体重百分位数评分衡量）是EUGR的高度预测指标（p<0.001）。当考虑EUGR其他预测因素的独立作用时，一旦考虑出生体重的影响，只有全胃肠外营养天数（p<0.001）和恢复出生体重时的头围百分位数（p<0.001）对EUGR的预测有显著贡献。
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