Knuiman M W, Divitini M L, Olynyk J K, Cullen D J, Bartholomew H C
School of Population Health, The University of Western Australia, Crawley, Western Australia, Australia.
Am J Epidemiol. 2003 Jul 15;158(2):144-9. doi: 10.1093/aje/kwg121.
The association between serum ferritin level and coronary heart disease (CHD) and stroke events was evaluated in a long-term Western Australia prospective study in 1981-1998. The cohort consisted of the 1612 men and women aged 40-89 years who participated in the 1981 Busselton Health Survey and who were free of cardiovascular disease at that time. Serum ferritin levels were obtained from serum samples stored frozen since 1981. The outcomes of interest were time to first CHD event (hospital admission or death) and time to first stroke event. Case-cohort sampling was used to reduce costs and preserve serum but still allow efficient analysis. Ferritin assays were performed for 217 CHD cases, 118 stroke cases, and a random sample of 450 of the total cohort. Proportional hazards regression models were used to obtain age-adjusted and multivariate-adjusted hazard ratios for ferritin level in relation to CHD and stroke. The hazard ratio for the highest tertile group compared with the lowest group was 0.96 (95% confidence interval: 0.60, 1.53) for CHD and 1.43 (95% confidence interval: 0.78, 2.64) for stroke. Little or no evidence was found that ferritin level was a risk factor for cardiovascular disease.
在1981 - 1998年西澳大利亚的一项长期前瞻性研究中，评估了血清铁蛋白水平与冠心病（CHD）及中风事件之间的关联。该队列由1612名年龄在40 - 89岁之间的男性和女性组成，他们参与了1981年的巴瑟尔顿健康调查，且当时无心血管疾病。血清铁蛋白水平取自自1981年起冷冻保存的血清样本。感兴趣的结局是首次发生冠心病事件（住院或死亡）的时间以及首次中风事件的时间。采用病例 - 队列抽样以降低成本并保存血清，但仍能进行有效分析。对217例冠心病病例、118例中风病例以及整个队列中随机抽取的450例样本进行了铁蛋白检测。使用比例风险回归模型来获取铁蛋白水平与冠心病和中风相关的年龄调整及多变量调整风险比。与最低组相比，最高三分位数组的冠心病风险比为0.96（95%置信区间：0.60，1.53），中风风险比为1.43（95%置信区间：0.78，2.64）。几乎没有证据表明铁蛋白水平是心血管疾病的危险因素。
Zotero 插件