Grigor'ian R A, Sollertinskaia T N
I.M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Acad. Sci., 194223, St. Petersburg, pr. M. Toreza, 44, Russia.
Ross Fiziol Zh Im I M Sechenova. 2002 Dec;88(12):1543-9.
In rabbits, effects of s.c. administration of met-enkephaline (MET) and stimulation of hypothalamic nuclei upon vegetative and motor functions are similar and involve changes of the breathing rate, heart rate, and diminishing of the motor component of orienting responses. MET acts mainly upon cardiac parameters. Administration of naloxone eliminates the MET effect upon the vegetative and motor parameters. The role of opioid mechanism in regulation of the brain's visceral-motor function regulation, is emphasized.
在家兔中,皮下注射甲硫氨酸脑啡肽(MET)以及刺激下丘脑核团对植物性和运动功能的影响相似,包括呼吸频率、心率的改变以及定向反应运动成分的减弱。MET主要作用于心脏参数。给予纳洛酮可消除MET对植物性和运动参数的影响。强调了阿片样物质机制在调节大脑内脏运动功能中的作用。