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阿托伐他汀引发的自身免疫性肝炎。

Autoimmune hepatitis revealed by atorvastatin.

作者信息

Pelli Nicoletta, Setti Maurizio, Ceppa Paola, Toncini Carlo, Indiveri Francesco

机构信息

Department of Internal Medicine, Clinical Immunology Unit, University of Genoa, Genoa, Italy.

出版信息

Eur J Gastroenterol Hepatol. 2003 Aug;15(8):921-4. doi: 10.1097/00042737-200308000-00014.

Abstract

Cases of acute hepatitis induced by statins (3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors) have been reported. A 65-year-old woman was admitted to our hospital because of fatigue, jaundice and altered liver function tests while on treatment with atorvastatin. On the basis of clinical, serological and histological findings, a score leading to a diagnosis of autoimmune hepatitis was reached. We suggest that atorvastatin may have revealed an underlying autoimmune hepatitis.

摘要

已有他汀类药物(3-羟基-3-甲基戊二酰辅酶A还原酶抑制剂)诱发急性肝炎的病例报道。一名65岁女性在接受阿托伐他汀治疗期间因疲劳、黄疸及肝功能检查异常入住我院。根据临床、血清学及组织学检查结果,得出自身免疫性肝炎的诊断评分。我们认为阿托伐他汀可能暴露了潜在的自身免疫性肝炎。

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