Pelli Nicoletta, Setti Maurizio, Ceppa Paola, Toncini Carlo, Indiveri Francesco
Department of Internal Medicine, Clinical Immunology Unit, University of Genoa, Genoa, Italy.
Eur J Gastroenterol Hepatol. 2003 Aug;15(8):921-4. doi: 10.1097/00042737-200308000-00014.
Cases of acute hepatitis induced by statins (3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors) have been reported. A 65-year-old woman was admitted to our hospital because of fatigue, jaundice and altered liver function tests while on treatment with atorvastatin. On the basis of clinical, serological and histological findings, a score leading to a diagnosis of autoimmune hepatitis was reached. We suggest that atorvastatin may have revealed an underlying autoimmune hepatitis.
已有他汀类药物(3-羟基-3-甲基戊二酰辅酶A还原酶抑制剂)诱发急性肝炎的病例报道。一名65岁女性在接受阿托伐他汀治疗期间因疲劳、黄疸及肝功能检查异常入住我院。根据临床、血清学及组织学检查结果,得出自身免疫性肝炎的诊断评分。我们认为阿托伐他汀可能暴露了潜在的自身免疫性肝炎。