新型手性异金属四面体簇合物的高效液相色谱对映体拆分
Enantioseparation of novel chiral heterometal tetrahedral clusters by high-performance liquid chromatography.
作者信息
Zhu Xinyi, Cai Yingchun, Zhang Weiqiang, Chen Liren, Li Yongmin
机构信息
Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 73000, China.
出版信息
J Chromatogr A. 2003 Jun 20;1002(1-2):231-6. doi: 10.1016/s0021-9673(03)00655-1.
A series of novel chiral heterometal tetrahedral clusters have firstly been separated on cellulose tris-(3,5-dimethylphenylcarbamate) stationary phase by high-performance liquid chromatography using n-hexane as the mobile phase containing different alcohols as modifiers. The effects of concentration and structures of alcohols in the mobile phases and structures of chiral heterometal tetrahedral clusters on enantioseparation were investigated. The results showed that the concentration and structures of alcohols had large effects on enantioseparation. It also was found that both the metal in the tetrahedral core and the ligand coordinated to the atom in tetrahedral core had significant effects on their chromatographic behavior.
一系列新型手性异金属四面体簇合物首次在涂敷有三（3,5-二甲基苯基氨基甲酸酯）纤维素的固定相上，通过以正己烷为流动相并含有不同醇类作为改性剂的高效液相色谱法进行分离。研究了流动相中醇类的浓度和结构以及手性异金属四面体簇合物的结构对映体拆分的影响。结果表明，醇类的浓度和结构对映体拆分有很大影响。还发现四面体核心中的金属以及与四面体核心中的原子配位的配体对其色谱行为都有显著影响。
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