碳环1-[4-(羟甲基)环戊-2-烯基]-1,2,4-三唑-3-甲酰胺及其衍生物的合成
Synthesis of carbocyclic 1-[4-(hydroxymethyl)cyclopent-2-enyl]-1,2,4-triazole-3-carboxamide and its derivatives.
作者信息
An Gwang-il, Rhee Hakjune
机构信息
Department of Chemistry, Hanyang University, Ansan, Kyunggi-do, Korea.
出版信息
Nucleosides Nucleotides Nucleic Acids. 2003 Apr;22(4):437-51. doi: 10.1081/NCN-120022033.
PMID:12885124
Abstract
The synthesis of carbocyclic 1-[4-(hydroxymethyl)cyclopent-2-enyl]-1,2,4-triazole-3-carboxamide (6a) and its derivatives was achieved from triol 10 in excellent overall yield. This route involves a Pd(0)-catalyzed coupling reaction as a key step.
摘要
碳环1-[4-(羟甲基)环戊-2-烯基]-1,2,4-三唑-3-甲酰胺(6a)及其衍生物的合成以三醇10为原料，总收率优异。该路线以钯(0)催化的偶联反应为关键步骤。
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