前列腺特异性抗原（PSA）水平为4.0纳克/毫升或更低的男性，再次筛查间隔超过一年的可能性。

Possibility of re-screening intervals of more than one year in men with PSA levels of 4.0 ng/ml or less.

作者信息

Ito Kazuto, Yamamoto Takumi, Ohi Masaru, Takechi Hiroyuki, Kurokawa Kohei, Suzuki Kazuhiro, Yamanaka Hidetoshi

机构信息

Department of Urology, Gunma University School of Medicine, Gunma, Japan.

出版信息

Prostate. 2003 Sep 15;57(1):8-13. doi: 10.1002/pros.10268.

DOI:10.1002/pros.10268

PMID:12886518

Abstract

BACKGROUND

The optimal re-screening interval is one of the most important issues to evaluate the effectiveness of screening for prostate cancer.

METHODS

Between 1992 and 2000, 7,026 men aged 50-78 with baseline PSA levels of 4.0 ng/ml or lower underwent screening for prostate cancer twice or more. The risk of developing prostate cancer relative to elapsed years and baseline PSA levels were investigated.

RESULTS

Prostate cancer was detected in a total of 127 cases (1.8%). The detection rate of prostate cancer was high between 1.6% and 5.5% at 1 year after baseline PSA measurements in men with baseline PSA levels of 2.1-4.0 ng/ml. In men with baseline PSA levels of 1.1- 2.0 ng/ml, the detection rate increased from 0.06% to 1.02% with passed years. The proportion of stage >/=T3 was high at 63% in prostate cancer cases detected between 3 and 4 years after baseline PSA levels being 1.1-2.0 ng/ml. In men with baseline PSA levels of 1.0 or lower, the cumulative detection rate of prostate cancer was low at 0.01% within 3 years, however, the detection rate increased to 0.34% after 5 or more years from baseline PSA measurements.

CONCLUSIONS

The re-screening interval was recommended to be 1, 1-2, and 3-5 years for men with baseline PSA levels of 2.1-4.0 ng/ml, 1.1-2.0 ng/ml, and 1.0 ng/ml or lower, respectively.

摘要

背景

最佳复查间隔时间是评估前列腺癌筛查效果的最重要问题之一。

方法

1992年至2000年期间，7026名年龄在50 - 78岁、基线前列腺特异抗原（PSA）水平为4.0 ng/ml或更低的男性接受了两次或更多次前列腺癌筛查。研究了前列腺癌发病风险与时间及基线PSA水平的关系。

结果

共检测出127例前列腺癌（1.8%）。基线PSA水平为2.1 - 4.0 ng/ml的男性，在基线PSA测量后1年，前列腺癌检出率在1.6%至5.5%之间较高。基线PSA水平为1.1 - 2.0 ng/ml的男性，随着时间推移，检出率从0.06%增至1.02%。在基线PSA水平为1.1 - 2.0 ng/ml后的3至4年检测出的前列腺癌病例中，≥T3期的比例高达63%。基线PSA水平为1.0或更低的男性，3年内前列腺癌累积检出率低至0.01%，然而，从基线PSA测量5年或更长时间后，检出率增至0.34%。