鼻型结外自然杀伤/T细胞淋巴瘤异基因外周血干细胞移植术后食管放线菌病

Esophageal actinomycosis after allogeneic peripheral blood stem cell transplantation for extranodal natural killer/T cell lymphoma, nasal type.

作者信息

Yagi T, Fujino H, Hirai M, Inoue T, Sako M, Teshima H, Fujii S, Hino M

机构信息

Department of Laboratory Medicine, Osaka City General Hospital, Miyakojimahondori, Miyakojima-ku, Osaka, Japan.

出版信息

Bone Marrow Transplant. 2003 Aug;32(4):451-3. doi: 10.1038/sj.bmt.1704161.

DOI:10.1038/sj.bmt.1704161

PMID:12900786

Abstract

We report a 19-year-old man with extranodal natural killer (NK)/T cell lymphoma, nasal type treated by allogeneic peripheral blood stem cell transplantation (allo-PBSCT). His lymphoma was chemoresistant, and disseminated during local radiotherapy. The patient received allo-PBSCT from his HLA-1 locus mismatched sister using busulfan (BU), cyclophosphamide (CY) and VP-16 as the conditioning regimen. His course was complicated by esophageal actinomycosis 9 months after transplantation, which resulted in the rupture of the right common carotid artery. These observations suggest that actinomycosis should be monitored carefully after transplantation in patients who have received local radiation therapy before the procedure.

摘要

我们报告了一名19岁的男性，患有结外自然杀伤（NK）/T细胞淋巴瘤，鼻型，接受了异基因外周血干细胞移植（allo-PBSCT）治疗。他的淋巴瘤对化疗耐药，并在局部放疗期间播散。患者使用白消安（BU）、环磷酰胺（CY）和依托泊苷（VP-16）作为预处理方案，接受了来自其HLA-1位点不匹配姐姐的allo-PBSCT。移植后9个月，他的病程并发食管放线菌病，导致右颈总动脉破裂。这些观察结果表明，对于在移植前接受过局部放疗的患者，移植后应仔细监测放线菌病。