[腹水球蛋白对小鼠白血病P388/DOX及艾氏癌生长的影响]
[The effect of ascitic fluid globulins on the growth of leukemia P388/DOX and Ehrlich's carcinoma in mice].
作者信息
Donenko F V, Kabieva A O, Moroz L V
出版信息
Biull Eksp Biol Med. 1992 Nov;114(11):518-9.
PMID:1290828
Abstract
The study was performed to investigate the effect of ascitic fluid globulins of tumor on tumor growth and life span of mice. The globulins are shown to shorten the life span of Ehrlich tumor mice from 86.8 to 61.8 days, to increase 3-5-fold the growth rate of Ehrlich carcinoma and P388/DOX tumor. It was found that globulins of ascitic fluids and serum globulins of tumor have equal effects of tumor growth. It is proposed to use globulins of ascitic fluid to study the globulin role in tumor growth.
摘要
本研究旨在探讨肿瘤腹水球蛋白对小鼠肿瘤生长及寿命的影响。结果显示，这些球蛋白可使艾氏腹水癌小鼠的寿命从86.8天缩短至61.8天，并使艾氏腹水癌和P388/DOX肿瘤的生长速率提高3至5倍。研究发现，腹水球蛋白与肿瘤血清球蛋白对肿瘤生长的影响相同。建议利用腹水球蛋白来研究球蛋白在肿瘤生长中的作用。
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