Lamme B, Boerma D, Boermeester M A, Gouma D J
Academisch Medisch Centrum/Universiteit van Amsterdam, afd. Heelkunde, Meibergdreef 9, 1105 AZ Amsterdam.
Ned Tijdschr Geneeskd. 2003 Jul 26;147(30):1437-41.
In three patients, a 44-year-old schizophrenic woman and two men aged 54 and 42, who presented with dyspnoea, a pancreaticopleural fistula was diagnosed as a complication of pancreatitis, i.e. a fistulous tract between the pancreas and the pleural cavity. In general, these fistulas have a good prognosis; however, delay in finding the correct diagnosis influences the prognosis. This is often due to unfamiliarity with the disease and the non-specific presentation of patients with pleural effusion. The initial presentation usually comprises respiratory (dyspnoea, coughing due to pleural effusion) and occasional abdominal symptoms (epigastric pain). A definitive diagnosis is made when elevated pleural effusion amylase levels are demonstrated. Surgical treatment is only indicated if conservative or endoscopic treatment fails, and consists of resection of the fistula and drainage of the pancreatic duct via a lateral pancreaticojejunostomy or resection of the part of the pancreas where the fistula originates. In the first patient, surgical drainage of the fluid accumulation was applied, but she died of aspiration pneumonia after she had removed the feeding tube and had refused further treatment. Pancreatic resection resulted in recovery in the two men.
在三名患者中,一名44岁的精神分裂症女性以及两名分别为54岁和42岁的男性,他们均表现出呼吸困难,经诊断患有胰胸膜瘘,这是胰腺炎的一种并发症,即胰腺与胸膜腔之间存在瘘管。一般来说,这些瘘管预后良好;然而,诊断延误影响预后。这通常是由于对该疾病不熟悉以及胸腔积液患者的表现不具有特异性所致。最初的表现通常包括呼吸系统症状(呼吸困难、因胸腔积液引起的咳嗽)以及偶尔的腹部症状(上腹部疼痛)。当胸腔积液淀粉酶水平升高时可做出明确诊断。仅在保守治疗或内镜治疗失败时才考虑手术治疗,手术包括切除瘘管并通过侧侧胰空肠吻合术引流胰管或切除瘘管起源部位的部分胰腺。在第一名患者中,对积液进行了手术引流,但她在拔除饲管并拒绝进一步治疗后死于吸入性肺炎。两名男性患者经胰腺切除后康复。