外周电刺激对大鼠吗啡诱导的位置偏爱恢复及海洛因成瘾者药物渴求的抑制作用。
Inhibition by peripheral electric stimulation of the reinstatement of morphine-induced place preference in rats and drug-craving in heroin addicts.
作者信息
Wang Bin, Zhang Benguo, Ge Xuecai, Luo Fei, Han Jisheng
机构信息
Neuroscience Research Institute, Department of Neurobiology, Peking University, Beijing 100083, China.
出版信息
Beijing Da Xue Xue Bao Yi Xue Ban. 2003 Jun 18;35(3):241-7.
OBJECTIVE
To test the hypothesis that peripheral electric stimulation (PES) may suppress the reinstatement of morphine-induced conditioned place preference (CPP) in rats as well as the drug craving of detoxified heroin addicts in a frequency-dependent manner.
METHODS
CPP model of the rat was constructed with two compartment automatic CPP apparatus, and the craving of the heroin addicts was assessed with a visual analogue scale (VAS).
RESULTS
(1) PES of low frequency could prevent the drug priming- or foot shock-induced reinstatement of morphine CPP; (2) this effect was naloxone-reversible, suggesting a possible involvement of endogenous opioid mechanisms; and (3) PES of low frequency could also accelerate the rate of natural decay of drug craving in heroin addicts after successful abstinence.
CONCLUSION
PES might serve as a therapeutic measure for the treatment of heroin addiction.
目的
验证外周电刺激（PES）可能以频率依赖的方式抑制大鼠吗啡诱导的条件性位置偏爱（CPP）的恢复以及脱毒海洛因成瘾者的药物渴求这一假说。
方法
使用两室自动CPP装置构建大鼠CPP模型，并用视觉模拟量表（VAS）评估海洛因成瘾者的渴求程度。
结果
（1）低频PES可预防药物激发或足部电击诱导的吗啡CPP恢复；（2）该效应可被纳洛酮逆转，提示内源性阿片机制可能参与其中；（3）低频PES还可加速海洛因成瘾者成功戒断后药物渴求的自然衰减速度。
结论
PES可能作为治疗海洛因成瘾的一种治疗措施。
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