Alekseenko A V, Patratiĭ V K, Iftodiĭ A G, Tarabanchuk V V, Shcherban N G
Klin Khir (1962). 1992(9-10):16-7.
At experimental investigations on 38 adult dogs for studying pharmacokinetics of kanamycin in the bile and liver tissue under the influence of the electric field of constant current, the increase in concentration of the preparation as compared with that in the control group was established. Optimal concentration of kanamycin retained for 14-16 h. Clinical study has shown the high effectiveness of the method for treatment of acute cholangitis suggested.
在对38只成年犬进行的实验研究中,为了研究在恒定电流电场影响下卡那霉素在胆汁和肝组织中的药代动力学,发现与对照组相比,制剂浓度有所增加。卡那霉素的最佳浓度可维持14 - 16小时。临床研究表明,所建议的治疗急性胆管炎的方法具有很高的有效性。