山竹果中氧杂蒽酮类化合物对人白血病细胞系凋亡的诱导作用。
Induction of apoptosis by xanthones from mangosteen in human leukemia cell lines.
作者信息
Matsumoto Kenji, Akao Yukihiro, Kobayashi Emi, Ohguchi Kenji, Ito Tetsuro, Tanaka Toshiyuki, Iinuma Munekazu, Nozawa Yoshinori
机构信息
Gifu International Institute of Biotechnology, 1-1 Naka-Fudogaoka, Kakamigahara, Gifu 504-0838, Japan.
出版信息
J Nat Prod. 2003 Aug;66(8):1124-7. doi: 10.1021/np020546u.
PMID:12932141
Abstract
We examined the effects of six xanthones from the pericarps of mangosteen, Garcinia mangostana, on the cell growth inhibition of human leukemia cell line HL60. All xanthones displayed growth inhibitory effects. Among them, alpha-mangostin showed complete inhibition at 10 microM through the induction of apoptosis.
摘要
我们研究了山竹（莽吉柿）果皮中的六种氧杂蒽酮对人白血病细胞系HL60细胞生长抑制的影响。所有氧杂蒽酮均表现出生长抑制作用。其中，α-倒捻子素在10微摩尔浓度时通过诱导细胞凋亡表现出完全抑制作用。
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