阿尔茨海默病中β-分泌酶（BACE）和糖原合成酶激酶-3（GSK-3）的mRNA水平
Beta-secretase (BACE) and GSK-3 mRNA levels in Alzheimer's disease.
作者信息
Preece Paul, Virley David J, Costandi Moheb, Coombes Robert, Moss Stephen J, Mudge Anne W, Jazin Elena, Cairns Nigel J
机构信息
Quantuum, Departamento de Neurología, Rua das Brañas 7-bajo-D, Mera, La Coruña, Galicia 15177, Spain.
出版信息
Brain Res Mol Brain Res. 2003 Aug 19;116(1-2):155-8. doi: 10.1016/s0169-328x(03)00233-x.
Beta-secretase (BACE) and glycogen synthase kinase (GSK 3) are two enzymes thought to play a role in Alzheimer's disease. We extracted mRNA from 90 Alzheimer and 81 control brains. Levels of mRNA were quantified for BACE and GSK 3 with TaqMan real-time RT-PCR. We found no change in the Alzheimer's disease brains relative to controls for either the BACE or the GSK 3alpha mRNA levels.
β-分泌酶（BACE）和糖原合酶激酶（GSK 3）是被认为在阿尔茨海默病中起作用的两种酶。我们从90例阿尔茨海默病患者和81例对照者的大脑中提取了mRNA。使用TaqMan实时逆转录聚合酶链反应对BACE和GSK 3的mRNA水平进行定量。我们发现，与对照组相比，阿尔茨海默病患者大脑中的BACE或GSK 3α mRNA水平均未发生变化。
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