外源性给予白细胞介素-10在实验性自身免疫性睾丸炎中的促炎作用。

Proinflammatory effects of exogenously administered IL-10 in experimental autoimmune orchitis.

作者信息

Kaneko Tetsushi, Itoh Masahiro, Nakamura Yoichi, Iimura Akira, Hayashi Shogo, Takahashi Kodo, Stivala Franca, Bendtzen Klaus, Nicoletti Ferdinando

机构信息

Department of Anatomy, Tokyo Medical University, Shinjuku 6-1-1, Shinjuku-ku Tokyo, Japan.

出版信息

Cytokine. 2003 Apr;22(1-2):50-3. doi: 10.1016/s1043-4666(03)00103-0.

DOI:10.1016/s1043-4666(03)00103-0

PMID:12946105

Abstract

We studied the effects of exogenously administered recombinant murine interleukin (IL)-10 on the development of experimental autoimmune orchitis (EAO) in C3H/He mice. IL-10 significantly augments histological signs of EAO when administered for 6 consecutive days from days 15 to 20 after primary immunisations with testicular germ cells. These data demonstrate that IL-10, in addition to its well-known antiinflammatory property, also has proinflammatory functions capable of up-regulating testicular immunoinflammatory processes in vivo.

摘要

我们研究了外源性给予重组鼠白细胞介素（IL）-10对C3H/He小鼠实验性自身免疫性睾丸炎（EAO）发展的影响。在用睾丸生殖细胞进行初次免疫后的第15至20天连续6天给予IL-10时，IL-10显著增强了EAO的组织学特征。这些数据表明，IL-10除了具有其众所周知的抗炎特性外，还具有能够在体内上调睾丸免疫炎症过程的促炎功能。