Lang Jing-he, Zhao Xue-ying
Department of Obstetrics and Gynecology, PUMC Hospital, CAMS and PUMC, Beijing 100730, China.
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2003 Aug;25(4):377-80.
To reduce extensive radical procedures and decrease morbidity in gynecologic malignancies, much effort is being focused on implementing less aggressive interventions. Two different approaches such as lymphatic mapping and lymphoscintigraphy are currently used to identify sentinel lymph nodes. In vulvar and cervical carcinomas, metastatic spread of disease commonly follows stepwise progressive drainage. Thus, sentinel lymph node identification may significantly reduce the number of patients undergoing unnecessary, extensive lymphadenectomy in the absence of metastatic disease. The addition of novel techniques, such as histopathologic ultrastaging, step sectioning, and immunohistochemistry staining, will help increase the accuracy and rate of detection of the disease. Any definitive statements can be made to the validity of sentinel lymphadenectomy until we got data with long-term follow-up.
为减少妇科恶性肿瘤的广泛根治性手术并降低发病率,目前正致力于实施侵入性较小的干预措施。目前使用两种不同方法,如淋巴绘图和淋巴闪烁显像来识别前哨淋巴结。在外阴癌和宫颈癌中,疾病的转移扩散通常呈逐步进展的引流方式。因此,在不存在转移性疾病的情况下,识别前哨淋巴结可能会显著减少接受不必要的广泛淋巴结清扫术的患者数量。添加新技术,如组织病理学超分期、连续切片和免疫组织化学染色,将有助于提高疾病的检测准确性和检出率。在获得长期随访数据之前,无法对前哨淋巴结清扫术的有效性做出任何明确的陈述。