环磷酰胺治疗霍奇金病后发生的膀胱癌。
Urinary bladder cancer following cyclophosphamide therapy for Hodgkin's disease.
作者信息
Pathak A B, Advani S H, Gopal R, Nadkarni K S, Saikia T K
机构信息
Department of Medical Oncology, Tata Memorial Hospital, Parel, Bombay, India.
出版信息
Leuk Lymphoma. 1992 Dec;8(6):503-4. doi: 10.3109/10428199209051035.
PMID:1297484
Abstract
Urinary bladder cancers following prolonged cyclophosphamide therapy are being increasingly reported. We report a case of transitional cell carcinoma of the urinary bladder occurring 12 years after pulse intravenous therapy with cyclophosphamide for Hodgkin's disease. The mechanism of bladder carcinogenesis and the possible role of the uroprotector MESNA in preventing cyclophosphamide induced bladder cancer are discussed.
摘要
长期使用环磷酰胺治疗后发生膀胱癌的病例报告日益增多。我们报告1例霍奇金病患者在接受环磷酰胺脉冲静脉治疗12年后发生膀胱移行细胞癌。本文讨论了膀胱癌的发生机制以及尿路保护剂美司钠在预防环磷酰胺诱导的膀胱癌中可能发挥的作用。
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