[Influence of long-term hemodialysis treatment on total and free thyroxine serum concentration in patients with chronic renal failure].

UNLABELLED

Many disturbances in functioning of pituitary-thyroid axis in patients with advanced chronic renal failure are well documented. The present paper aimed to assess the influence of duration of haemodialysis treatment on basal and after stimulating TT4 and fT4 serum concentration in uraemic patients. 17 nondialyzed uraemic patients, 15 dialysed up to 50 months, 11 dialysed for 51-100 months, 11 dialysed for more than 100 months and 14 control subjects were examined. In all subjects TT4 and fT4 levels were assessed before and after TRH administration (400 micrograms/i.v.).

RESULTS

1. The patients, independently if the duration of dialysis therapy, did not show any significant differences in basal TT4 from the normal subjects. 2. Nondialyzed and patients dialysed up to 50 months showed significantly lower basal values of fT4 as compared with the patients dialysed longer and with normal subjects. 3. Areas over basal values of TT4 did not show any significant differences in all examined groups. 4. Areas over basal fT4 values were significantly higher in the patients dialysed over 50 months than in the remaining groups. 5. Positive significant correlations were found between the duration of dialysis therapy and basal fT4 as well as area over basal fT4 values.

CONCLUSION

Duration of haemodialysis treatment significantly influences the fT4 serum concentration in chronic renal failure.