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无抗钙通道抗体的兰伯特-伊顿肌无力综合征：钙拮抗剂地尔硫䓬的不良反应

Lambert-Eaton myasthenic syndrome without anti-calcium channel antibody: adverse effect of calcium antagonist diltiazem.

作者信息

Ueno S, Hara Y

机构信息

Second Department of Internal Medicine, Osaka University Medical School, Japan.

出版信息

J Neurol Neurosurg Psychiatry. 1992 May;55(5):409-10. doi: 10.1136/jnnp.55.5.409.

DOI:10.1136/jnnp.55.5.409
PMID:1318359
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC489088/
Abstract

A 59 year old man with ischaemic heart disease, developed the clinical and electromyographic changes of the Lambert-Eaton myasthenic syndrome after taking calcium antagonist, diltiazem. The symptoms appeared periodically with a rise and fall in serum level of diltiazem. Extensive search was made for systemic neoplasms and autoimmune diseases without success. Serum antibody to voltage operated calcium channel was not detected.

摘要

一名59岁患有缺血性心脏病的男性，在服用钙拮抗剂地尔硫䓬后出现了兰伯特-伊顿肌无力综合征的临床和肌电图改变。症状随血清地尔硫䓬水平的升降而周期性出现。对全身性肿瘤和自身免疫性疾病进行了广泛排查，但未获结果。未检测到针对电压门控钙通道的血清抗体。

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Lambert-Eaton myasthenic syndrome without anti-calcium channel antibody: adverse effect of calcium antagonist diltiazem.无抗钙通道抗体的兰伯特-伊顿肌无力综合征：钙拮抗剂地尔硫䓬的不良反应
J Neurol Neurosurg Psychiatry. 1992 May;55(5):409-10. doi: 10.1136/jnnp.55.5.409.
2
Exacerbation of symptoms due to diltiazem in a patient with Lambert-Eaton myasthenic myopathic syndrome.
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3
[Lambert-Eaton syndrome].[兰伯特-伊顿综合征]
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[Lambert-Eaton syndrome without calcium channel autoantibodies].无钙通道自身抗体的兰伯特-伊顿综合征
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Calcium-channel antibodies in the Lambert-Eaton syndrome and other paraneoplastic syndromes.兰伯特-伊顿综合征及其他副肿瘤综合征中的钙通道抗体。
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Long-term observation of incremental response and antibodies to voltage-gated calcium channels in patients with Lambert-Eaton myasthenic syndrome: two case reports.兰伯特-伊顿肌无力综合征患者对电压门控钙通道的递增反应及抗体的长期观察：两例报告
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Calcium channel autoantibodies in Lambert-Eaton myasthenic syndrome.兰伯特-伊顿肌无力综合征中的钙通道自身抗体。
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[Anti-voltage-gated calcium channel antibodies in the Lambert-Eaton myasthenic syndrome].[兰伯特-伊顿肌无力综合征中的抗电压门控钙通道抗体]
Rinsho Shinkeigaku. 1994 Oct;34(10):980-4.
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Calcium channel autoantibodies in the Lambert-Eaton myasthenic syndrome.兰伯特-伊顿肌无力综合征中的钙通道自身抗体。
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引用本文的文献

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Ca2+ channels as targets of neurological disease: Lambert-Eaton Syndrome and other Ca2+ channelopathies.作为神经疾病靶点的钙离子通道：兰伯特-伊顿综合征及其他钙离子通道病
J Bioenerg Biomembr. 2003 Dec;35(6):697-718. doi: 10.1023/b:jobb.0000008033.02320.10.
2
Passive transfer of Lambert-Eaton syndrome to mice induces dihydropyridine sensitivity of neuromuscular transmission.将兰伯特-伊顿综合征被动转移至小鼠会诱导神经肌肉传递的二氢吡啶敏感性。
J Physiol. 2002 Sep 1;543(Pt 2):567-76. doi: 10.1113/jphysiol.2002.021048.

本文引用的文献

1
Passive transfer of Lambert-Eaton myasthenic syndrome with IgG from man to mouse depletes the presynaptic membrane active zones.将患兰伯特－伊顿肌无力综合征患者的IgG被动转移至小鼠体内，会使突触前膜活性区减少。
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Effects of diltiazem and verapamil on responses to acetylcholine.地尔硫䓬和维拉帕米对乙酰胆碱反应的影响。
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The Lambert-Eaton myasthenic syndrome. A review of 50 cases.兰伯特-伊顿肌无力综合征。50例病例回顾。
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Specificity of calcium channel autoantibodies in Lambert-Eaton myasthenic syndrome.
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Multiple types of neuronal calcium channels and their selective modulation.多种类型的神经元钙通道及其选择性调节。
Trends Neurosci. 1988 Oct;11(10):431-8. doi: 10.1016/0166-2236(88)90194-4.
10
[Eaton-Lambert syndrome manifested by respiratory failure associated with small cell carcinoma of the lung].以呼吸衰竭为表现的伊顿-兰伯特综合征与肺小细胞癌相关
Rinsho Shinkeigaku. 1990 Jul;30(7):780-3.