一名获得性免疫缺陷综合征血友病患者的播散性卡氏肺孢子虫感染。

Disseminated Pneumocystis carinii infection in a hemophiliac patient with acquired immunodeficiency syndrome.

作者信息

Wakabayashi T, Oka S, Shimada K, Nakano I, Iwatsubo T, Mori S

机构信息

Department of Pathology, University of Tokyo, Japan.

出版信息

Acta Pathol Jpn. 1992 Apr;42(4):262-6. doi: 10.1111/j.1440-1827.1992.tb02539.x.

DOI:10.1111/j.1440-1827.1992.tb02539.x

PMID:1319101

Abstract

A case of disseminated Pneumocystis carinii (PC) infection in a 28-year-old Japanese male hemophiliac with acquired immunodeficiency syndrome (AIDS) is reported. The patient had displayed a high fever and diffuse faint interstitial infiltrates on chest X-ray films without dyspnea three months before his death. At that time, no PC was detected after four consecutive induced sputum tests. Serum anti-cytomegalovirus (CMV) IgM was positive by EIA. No treatment for PC and CMV was given at the patient's request. Autopsy findings disclosed disseminated PC infection consisting of granulomas with caseation-like necrosis and frothy exudate in the lungs and disseminated organized calcification in the blood vessels of extrapulmonary organs. PC cysts and/or trophozoites were detected in these lesions.

摘要

报告了一例28岁患获得性免疫缺陷综合征（AIDS）的日本男性血友病患者播散性卡氏肺孢子虫（PC）感染病例。该患者在死亡前三个月出现高热，胸部X线片显示弥漫性模糊的间质浸润，但无呼吸困难。当时，连续四次诱导痰检均未检测到PC。酶免疫测定显示血清抗巨细胞病毒（CMV）IgM呈阳性。应患者要求，未对PC和CMV进行治疗。尸检结果显示为播散性PC感染，肺部有肉芽肿伴干酪样坏死和泡沫状渗出物，肺外器官血管有播散性机化性钙化。在这些病变中检测到PC囊肿和/或滋养体。