兔脑新型兰尼碱受体/钙释放通道的一级结构与分布

Primary structure and distribution of a novel ryanodine receptor/calcium release channel from rabbit brain.

作者信息

Hakamata Y, Nakai J, Takeshima H, Imoto K

机构信息

Department of Medical Chemistry, Kyoto University Faculty of Medicine, Japan.

出版信息

FEBS Lett. 1992 Nov 9;312(2-3):229-35. doi: 10.1016/0014-5793(92)80941-9.

DOI:10.1016/0014-5793(92)80941-9

PMID:1330694

Abstract

The complete amino acid sequence of a novel ryanodine receptor/calcium release channel from rabbit brain has been deduced by cloning and sequence analysis of the cDNA. This protein is composed of 4872 amino acids and shares characteristic structural features with the skeletal muscle and cardiac ryanodine receptors. RNA blot hybridization analysis shows that the brain ryanodine receptor is abundantly expressed in corpus striatum, thalamus and hippocampus, whereas the cardiac ryanodine receptor is more uniformly expressed in the brain. The brain ryanodine receptor gene is transcribed also in smooth muscle.

摘要

通过对cDNA进行克隆和序列分析，已推导出来自兔脑的一种新型兰尼碱受体/钙释放通道的完整氨基酸序列。该蛋白质由4872个氨基酸组成，并与骨骼肌和心肌兰尼碱受体具有特征性结构特征。RNA印迹杂交分析表明，脑兰尼碱受体在纹状体、丘脑和海马中大量表达，而心脏兰尼碱受体在脑中表达更为均匀。脑兰尼碱受体基因在平滑肌中也有转录。