给予二氧化碳后对猫体内美加明作用的影响。
The effects of mecamylamine in the cat as modified by the administration of carbon dioxide.
作者信息
PAYNE J P, ROWE G G
出版信息
Br J Pharmacol Chemother. 1957 Dec;12(4):457-60. doi: 10.1111/j.1476-5381.1957.tb00165.x.
Abstract
A series of cats, anaesthetized with chloralose, was given intravenously a sufficient quantity of mecamylamine to produce hypotension and a 50% neuromuscular block. Inhalation of carbon dioxide then produced a further depression of blood pressure and an increase in the neuromuscular blocking effect. It was shown that, following the administration of carbon dioxide, the plasma mecamylamine levels increased coincident with the increased pharmacological effects.
摘要
给一系列用氯醛糖麻醉的猫静脉注射足量的美加明，以产生低血压和50%的神经肌肉阻滞。然后吸入二氧化碳会导致血压进一步下降，并增强神经肌肉阻滞作用。结果表明，在给予二氧化碳后，血浆美加明水平升高，同时药理作用增强。
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本文引用的文献
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Mecamylamine and its mode of action.美加明及其作用方式。
Lancet. 1957 Aug 3;273(6988):218-22. doi: 10.1016/s0140-6736(57)91598-2.
2
Renal elimination of 3-methylaminoisocamphane hydrochloride (mecamylamine).盐酸3-甲基氨基异莰烷（美加明）的肾脏排泄
Am J Physiol. 1956 Jul;186(1):180-6. doi: 10.1152/ajplegacy.1956.186.1.180.
3
Ganglionic blocking properties of 3-methylaminoisocamphane hydrochloride (mecamylamine): a secondary amine.盐酸3-甲基氨基异莰烷（美加明）的神经节阻断特性：一种仲胺。
J Pharmacol Exp Ther. 1956 Jun;117(2):169-83.
4
The methonium.甲氧铵盐
Pharmacol Rev. 1952 Sep;4(3):219-53.
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