T细胞抗原受体基因α和β的突变在不同阶段阻断胸腺细胞发育。
Mutations in T-cell antigen receptor genes alpha and beta block thymocyte development at different stages.
作者信息
Mombaerts P, Clarke A R, Rudnicki M A, Iacomini J, Itohara S, Lafaille J J, Wang L, Ichikawa Y, Jaenisch R, Hooper M L
机构信息
Howard Hughes Medical Institute, Center for Cancer Research, Cambridge, Massachusetts.
出版信息
Nature. 1992 Nov 19;360(6401):225-31. doi: 10.1038/360225a0.
Analysis of mice carrying mutant T-cell antigen receptor (TCR) genes indicates that TCR-beta gene rearrangement or expression is critical for the differentiation of CD4-CD8- thymocytes to CD4+CD8+ thymocytes, as well as for the expansion of the pool of CD4+CD8+ cells. TCR-alpha is irrelevant in these developmental processes. The development of gamma delta T cells does not depend on either TCR-alpha or TCR-beta.
对携带突变型T细胞抗原受体（TCR）基因的小鼠进行分析表明，TCR-β基因重排或表达对于CD4-CD8-胸腺细胞向CD4+CD8+胸腺细胞的分化以及CD4+CD8+细胞池的扩增至关重要。TCR-α在这些发育过程中无关紧要。γδT细胞的发育不依赖于TCR-α或TCR-β。
Zotero 插件